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October 27, 2009

Free lunch?

There's a running joke on campus that if you try hard enough, you can eat lunch all week by going to seminars.

That's true this week.  And if you've been doing it, you heard some amazing speakers!

Last Friday, Michael Hopkins from the University of Chicago talked about building artificial photosynthesis systems from inorganic materials.

On Monday, Jacob Hale from Purdue University spoke on "Molecular Motion: Interpreting the Dance."  His talk highlighted molecular motion of single proteins in a membrane using both experimental data and modeling techniques to refine our understanding of how membranes "work."

Today, Martin Gruebele from the University of Illinois gave a talk entitled "How molecules resemble spacecraft, and how proteins fold in cells."  The leap from transition states of simple molecules to protein folding may seem like a huge one, but Dr. Gruebele's analogy of using the gravitational force of planets to minimize the energy needed to take a longer but more efficient route made it all fit together.

And on Thursday, Jeffery Elmendorf from the Indiana University School of Medicine will be talking about "Membrane cholesterol and the Road to Diabetes Type 2."  I don't know what's on the lunch menu, but there may be some irony if we're eating pizza and drinking soda during this one!

We are privileged to be able to host such a list of quality speakers.  It brings depth and relevance to what we teach in class, and helps all of us keep up with cutting edge research.

What's amazing is that these are just the science talks that happened this week.  It doesn't include the African Art Exhibit and associated talks, the Multicultural Festival events, an Ancient Greek sculpture and culture, or Moot Court Finals

So Wednesday is the only day you're on your own for lunch.  Use it wisely!

October 14, 2009

Instrumentation and integration

Tuesday the Chemistry of Cancer class donned disposable white lab coats and safety glasses in their visit to Endocyte,  a start-up chemotherapy targeting company in West Lafayette, IN.  The visit was the culmination of seven weeks of learning about DNA mutation, signal transduction, cell cycle, and apoptosis…and where these processes go wrong in cancer cells.  This involved integrating topics from biochemistry, cell biology, organic chemistry, and physiology.

Cancer therapeutic agents generally affect all dividing cells, including hair follicles, and epithelial cells which line the stomach and form your skin, leading to nasty side effects.  Endocyte is trying to target chemotherapy and imaging agents specifically to the cancer cells, leading to greater efficacy and fewer side effects.  We saw how all aspects of the process are integrated, from synthesizing, purifying, and analyzing potential compounds are to testing them in cells and animals for both specificity and effectiveness.

As part of the tour, Jeffrey Scott Nicoson '97 showed us the various analytical and separation instruments in the lab.  At one point, one of the other Endocyte employees asked the students if they had ever submitted a sample for NMR.

Matt Routh ’09 commented, “yeah, I ran some on our 400 MHz this morning.”  Our host was surprised to find out that not only did Wabash have a NMR spectrometer, but also the students regularly get to use it themselves, AND we have a higher powered instrument than they do!

Meanwhile, Nathan Line '10 appreciated the automatic chromatography system.  He’s continuing a research project he started during his summer internship at The Ohio State University, and appreciated its time saving aspects...but understood the budgetary trade-offs.   

The tour went an hour longer than we planned.  We made it back for afternoon classes and labs just in time…but it was worth every minute.  
 

This trip was made possible by the Know Indiana Grant from the Lilly Foundation.

October 09, 2009

Many paths to summer research

On campus, off campus. Wabash College, big university, industry. The diversity of research internships in Chemistry was very apparent at the Summer Research Symposium held on October 8. Four students gave oral presentations on how they obtained their research positions, while others gave poster presentations summarizing their summer research experiences.
 
Brandon Hirsh ‘10 used a contact made with a Chemistry Department seminar speaker, Dr. Srini Iyengar, to create an opportunity to do computational chemistry research at Indiana University last summer. His work was funded by a Dill Grant, a competitive Wabash award for independently arranged internships.  Andrew Alexander, ‘12 also used contacts to obtain an internship at Ball State University.
 Jake Lee ‘10 worked with Career Services to land an industrial research position at Valspar. Without contacts, industrial internships are hard to obtain, but Career Services connected Jake to an alum, and he had a great internship as a result.
Gabriel Stancu ’10 talked about his experiences working with Wally Novak here at Wabash.  Chad Sorenson ’10, Forrest Craig ’11, and Lucas Evans ’11 also did research in the Chemistry Department this summer.  These were all paid positions, funded either through the Haines Funds for the Study of Chemistry or Biochemistry and/or through external grants awarded to chemistry faculty members.
There are also nationally competitive Research Programs for Undergraduates, often sponsored by the National Science Foundation, called REU’s (Research Experiences for Undergraduates). Kenny Coggins ’11 sent out many applications, and landed a position at University of North Carolina at Chapel Hill. Nathan Line ’11 had a similar position at The Ohio State University, as did Merlin Liu '10 at the University of Minnesota.
If you’d like to learn more about their research experiences, plan to attend the Celebration of Student Research, Scholarship, and Creative Work in January, and watch for announcements about this summer’s research opportunities here at Wabash!